Article
Reconstructing the Qo site of Plasmodium falciparum bc 1 complex in the yeast enzyme.
PloS one - 1 Jan 2013
Vallières Cindy, Fisher Nicholas, Meunier Brigitte
Abstract excerpt
The bc 1 complex of the mitochondrial respiratory chain is essential for Plasmodium falciparum proliferation, the causative agent of human malaria. Therefore, this enzyme is an attractive target for antimalarials. However, biochemical investigations of the parasite enzyme needed for the study of new drugs are challenging. In order to facilitate the study of new compounds targeting the enzyme, we are modifying the...
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