Article
Equilibrative nucleotide transporter ENT3 (SLC29A3): A unique transporter for inherited disorders and cancers.
Experimental cell research - 15 Jan 2024
Ma Hongying, Qu Jian, Liao Yongkang, Liu Linxin, Yan Min, Wei Yiwen, Xu Weixin, Luo Jian, Dai Yuxin, Pang Zicheng, Qu Qiang
Abstract excerpt
As a crucial gene associated with diseases, the SLC29A3 gene encodes the equilibrative nucleoside transporter 3 (ENT3). ENT3 plays an essential regulatory role in transporting intracellular hydrophilic nucleosides, nucleotides, hydrophilic anticancer and antiviral nucleoside drugs, energy metabolism, subcellular localization, protein stability, and signal transduction. The mutation and inactivation of SLC29A3 are...
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