Pro64His (rs4644) Polymorphism Within Galectin-3 Is a Risk Factor of Differentiated Thyroid Carcinoma and Affects the Transcriptome of Thyrocytes Engineered via CRISPR/Cas9 System.

doi:10.1089/thy.2020.0366

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Article

Pro64His (rs4644) Polymorphism Within Galectin-3 Is a Risk Factor of Differentiated Thyroid Carcinoma and Affects the Transcriptome of Thyrocytes Engineered via CRISPR/Cas9 System.

Thyroid : official journal of the American Thyroid Association - 1 Jul 2021

Corrado Alda, Aceto Romina, Silvestri Roberto, Dell'Anno Irene, Ricci Benedetta, Miglietta Simona, Romei Cristina, Giovannoni Roberto, Poliseno Laura, Evangelista Monica, Vitiello Marianna, Cipollini Monica, Garritano Sonia, Giusti Laura, Zallocco Lorenzo, Elisei Rossella, Landi Stefano, Gemignani Federica

Abstract excerpt

Background: Galectin-3 (LGALS3) is an important glycoprotein involved in the malignant transformation of thyrocytes acting in the extracellular matrix, cytoplasm, and nucleus where it regulates TTF-1 and TCF4 transcription factors. Within LGALS3 gene, a common single-nucleotide polymorphism (SNP) (c.191C>A, p.Pro64His; rs4644) encoding for the variant Proline to Histidine at codon 64 has been extensively studied....

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PMID: 33308024
DOI: 10.1089/thy.2020.0366

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