Article
HLA-G 3' untranslated region polymorphic sites associated with increased HLA-G production are more frequent in patients exhibiting differentiated thyroid tumours.
Clinical endocrinology - 1 Apr 2017
de Figueiredo-Feitosa Nathalie Lobo, Martelli Palomino Gustavo, Cilião Alves Daiani Cristina, Mendes Junior Celso Teixeira, Donadi Eduardo Antonio, Maciel Léa Maria Zanini
Abstract excerpt
BACKGROUND: HLA-G is a nonclassical class I histocompatibility molecule implicated on the immune escape mechanism of tumour cells. We evaluated the genetic diversity of HLA-G 3' untranslated region (3'UTR) and associated polymorphic sites with clinical presentation and with the magnitude of HLA-G thyroid expression. PATIENTS AND METHODS: Polymorphic sites at 3'UTR (14bpINS/DEL, +3003C/T, +3010C/G, +3027A/C,...
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