PTCSC3 Is Involved in Papillary Thyroid Carcinoma Development by Modulating S100A4 Gene Expression.

doi:10.1210/jc.2015-2247

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Article

PTCSC3 Is Involved in Papillary Thyroid Carcinoma Development by Modulating S100A4 Gene Expression.

The Journal of clinical endocrinology and metabolism - 1 Oct 2015

Jendrzejewski Jaroslaw, Thomas Andrew, Liyanarachchi Sandya, Eiterman Andrew, Tomsic Jerneja, He Huiling, Radomska Hanna S, Li Wei, Nagy Rebecca, Sworczak Krzysztof, de la Chapelle Albert

Abstract excerpt

CONTEXT: We previously showed that a long noncoding RNA gene, PTCSC3, located close to the variant rs944289 that predisposes to papillary thyroid carcinoma (PTC) might target the S100A4 gene. OBJECTIVE: The aim was to investigate the impact of PTCSC3 on S100A4 expression and its role in cancer development. DESIGN: S100A4 abundance was analyzed by quantitative PCR (qPCR) in unaffected and tumor tissue from n = 73...

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PMID: 26274343
DOI: 10.1210/jc.2015-2247
PMCID: PMC4596031

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