A galectin-3 sequence polymorphism confers TRAIL sensitivity to human breast cancer cells.

doi:10.1002/cncr.26078

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Article

A galectin-3 sequence polymorphism confers TRAIL sensitivity to human breast cancer cells.

Cancer - 1 Oct 2011

Mazurek Nachman, Byrd James C, Sun Yunjie, Ueno Suguru, Bresalier Robert S

Abstract excerpt

BACKGROUND: A common polymorphism, rs4644, coding for Pro64 or His64 of the carbohydrate-binding protein galectin-3, influences the susceptibility of galectin-3 to cleavage by matrix metalloproteinases and is associated with breast cancer incidence. Because forced expression of galectin-3 in a galectin-3 null breast cancer cell line confers sensitivity to tumor necrosis factor-related apoptosis-inducing ligand...

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Identifiers

PMID: 21446041
DOI: 10.1002/cncr.26078
PMCID: PMC3164935

Genes

LGALS3

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