Article
[Fanconi's anemia: in vitro tests for the individualization of heterozygotes].
Giornale italiano di medicina del lavoro - 1 Jan 2000
Farulla A, Monaco E, Corrao C R, Cardoni F, Simonazzi S, Dallapiccola B
Abstract excerpt
Fanconi's anaemia (FA) is an autosomal recessive mutation associated with constitutional chromosome aberrations. Patient's cells show increased susceptibility to different mutagens, especially bifunctional alkylating agents. Asymptomatic heterozygotes have a population prevalence of 1 in 300, and have been considered at risk for cancers. It has also been shown that their cells are especially sensitive to some...
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