Article

Gut bacterial lactate stimulates lung epithelial mitochondria and exacerbates acute lung injury

2025-03-25

Abstract excerpt

<h4>ABSTRACT</h4> Acute respiratory distress syndrome (ARDS) is an often fatal critical illness where lung epithelial injury leads to intrapulmonary fluid accumulation. ARDS became widespread during the COVID-19 pandemic, motivating a renewed effort to understand the complex etiology of this disease. Rigorous prior work has implicated lung endothelial and epithelial injury in response to an insult such as bacteri...

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Literature Corpus work: 0e4b7c91-916f-584b-b83b-8c1745f75b16
DOI: 10.1101/2025.03.24.645052

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