Article

A Novel Subtype of Myeloproliferative Neoplasms Driven by a MYC-Alarmin Axis

2023-09-26

Abstract excerpt

<h4>ABSTRACT</h4> Despite advances in understanding the genetic abnormalities in myeloproliferative neoplasms (MPNs) and the development of JAK2 inhibitors, there is an urgent need to devise new treatment strategies, particularly for triple negative myelofibrosis (MF) patients whose MPNs lack mutations in the JAK2 kinase pathway and have very poor clinical outcomes. Here we report that MYC copy number gain and i...

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Literature Corpus work: e40b36dd-e6b1-506e-967b-35b21449bcd0
DOI: 10.1101/2023.09.25.559138

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