Article
Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage.
Nucleic acids research - 6 Sept 2018
Li Yinglu, Li Zhiming, Dong Liping, Tang Ming, Zhang Ping, Zhang Chaohua, Cao Ziyang, Zhu Qian, Chen Yongcan, Wang Hui, Wang Tianzhuo, Lv Danyu, Wang Lina, Zhao Ying, Yang Yang, Wang Haiying, Zhang Hongquan, Roeder Robert G, Zhu Wei-Guo
Abstract excerpt
Linker histone H1 has a key role in maintaining higher order chromatin structure and genome stability, but how H1 functions in these processes is elusive. Here, we report that acetylation of lysine 85 (K85) within the H1 globular domain is a critical post-translational modification that regulates chromatin organization. H1K85 is dynamically acetylated by the acetyltransferase PCAF in response to DNA damage, and...
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