Article
CD4+T cells in ageing-associated interstitial lung abnormalities show evidence of pro-inflammatory phenotypic and functional profile.
Thorax - 1 Feb 2021
Machahua Carlos, Buendia-Roldan Ivette, Ocaña-Guzman Ranferi, Molina-Molina María, Pardo Annie, Chavez-Galan Leslie, Selman Moises
Abstract excerpt
BACKGROUND: Interstitial lung abnormalities (ILA) occur in around 10% of subjects over 60 years, and are associated with a higher rate of all-cause mortality. The pathogenic mechanisms are unclear, and the putative contribution of alterations in the immune response has not been explored. Normal ageing is associated with immune deficiencies, including Naïve T-cell decrease and greater expression of the...
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