Article
Motor control and cognition deficits associated with protein carbamoylation in food (cassava) cyanogenic poisoning: Neurodegeneration and genomic perspectives.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Feb 2021
Rwatambuga F A, Ali E R, Bramble M S, Gosschalk J E, Kim Morris, Yandju D L, Okitundu L A, Boivin M J, Banea J P, Westaway S K, Larry D, Vilain Eric, Mumba Ngoyi D, Tshala-Katumbay D D
Abstract excerpt
A case-control design determined whether konzo, an upper motoneuron disease linked to food (cassava) toxicity was associated with protein carbamoylation and genetic variations. Exon sequences of thiosulfate sulfurtransferase (TST) or mercaptopyruvate sulfurtransferase (MPST), plasma cyanide detoxification rates, and 2D-LC-MS/MS albumin carbamoylation were assessed in 40 children [21 konzo-affected and 19...
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