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Article

Evidence for a functional genetic polymorphism of the human mercaptopyruvate sulfurtransferase (MPST), a cyanide detoxification enzyme.

Toxicology letters - 20 Aug 2006

Billaut-Laden Ingrid, Rat Emmanuel, Allorge Delphine, Crunelle-Thibaut Aurélie, Cauffiez Christelle, Chevalier Dany, Lo-Guidice Jean-Marc, Broly Franck

Abstract excerpt

Mercaptopyruvate sulfurtransferase (MPST) plays a central role in both cysteine degradation and cyanide detoxification. Moreover, deficiency in MPST activity has been suggested to be responsible for a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). To date, no mutation of the human MPST gene has been reported. We developed a screening strategy to search for mutations in the MPST...

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Share to Amino Acid Metabolism, Inborn Errors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyanides

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Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 16545926
DOI: 10.1016/j.toxlet.2006.02.002

Genes

MPST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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