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Dietary Non-protein Amino Acid AZE as an Environmental Trigger Activating Latent Genetic Susceptibility in <i>C9orf72</i> -ALS Pathogenesis

2026-01-13

Abstract excerpt

<h4>Summary</h4> In human disease, clinical manifestations are not always tightly correlated with genetic etiology. While the GGGGCC (G4C2) hexanucleotide repeat expansion in the C9orf72 gene is the most prevalent genetic cause of ALS, a subset of mutation carriers stays asymptomatic. The molecular mechanisms underlying this incomplete penetrance remain elusive. Here, we identify L-azetidine-2-carboxylic acid (A...

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Literature Corpus work
41a5faa0-07b4-523f-88e3-fc376110d54a
DOI
10.64898/2026.01.12.697838
Open publication

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Dietary Non-protein Amino Acid AZE as an Environmental Trigger Activating Latent Genetic Susceptibility in <i>C9orf72</i> -ALS PathogenesisDOI 10.64898/2026.01.12.697838
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