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Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections

9 May 2022

Abstract excerpt

Identification of host factors affecting individual SARS-CoV-2 susceptibility will provide a better understanding of the large variations in disease severity and will identify potential factors that can be used, or targeted, in antiviral drug development. With the use of an advanced lung cell model established from several human donors, we identified cellular protease inhibitors, serpins, as host factors that...

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PMID: 35532162
DOI: 10.1128/mbio.00892-22

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