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Article

The influence of regression models on genome-wide association studies of alcohol dependence: a comparison of binary and quantitative analyses.

Psychiatric genetics - 1 Feb 2021

Li Wenqianglong, Thygesen Johan Hilge, O'Brien Niamh Louise, Heydtmann Mathis, Smith Iain, Degenhardt Franziska, Nöthen Markus Maria, Morgan Marsha Yvonne, Bass Nicholas James, McQuillin Andrew

Abstract excerpt

INTRODUCTION: Genome-wide association studies (GWAS) of alcohol dependence syndrome (ADS) offer a platform to detect genetic risk loci. However, the majority of the ADS GWAS undertaken, to date, have utilized a case-control design and have failed to identify consistently replicable loci with the exception of protective variants within the alcohol metabolizing genes, notably ADH1B. The ADS phenotype shows...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 33290381
DOI: 10.1097/YPG.0000000000000268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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