Article
Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples.
Psychological medicine - 1 May 2021
Johnson Emma C, Sanchez-Roige Sandra, Acion Laura, Adams Mark J, Bucholz Kathleen K, Chan Grace, Chao Michael J, Chorlian David B, Dick Danielle M, Edenberg Howard J, Foroud Tatiana, Hayward Caroline, Heron Jon, Hesselbrock Victor, Hickman Matthew, Kendler Kenneth S, Kinreich Sivan, Kramer John, Kuo Sally I-Chun, Kuperman Samuel, Lai Dongbing, McIntosh Andrew M, Meyers Jacquelyn L, Plawecki Martin H, Porjesz Bernice, Porteous David, Schuckit Marc A, Su Jinni, Zang Yong, Palmer Abraham A, Agrawal Arpana, Clarke Toni-Kim, Edwards Alexis C
Abstract excerpt
BACKGROUND: Studies suggest that alcohol consumption and alcohol use disorders have distinct genetic backgrounds. METHODS: We examined whether polygenic risk scores (PRS) for consumption and problem subscales of the Alcohol Use Disorders Identification Test (AUDIT-C, AUDIT-P) in the UK Biobank (UKB; N = 121 630) correlate with alcohol outcomes in four independent samples: an ascertained cohort, the Collaborative...
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