Article
A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.
Biological psychiatry - 15 Sept 2011
Heath Andrew C, Whitfield John B, Martin Nicholas G, Pergadia Michele L, Goate Alison M, Lind Penelope A, McEvoy Brian P, Schrage Andrew J, Grant Julia D, Chou Yi-Ling, Zhu Rachel, Henders Anjali K, Medland Sarah E, Gordon Scott D, Nelson Elliot C, Agrawal Arpana, Nyholt Dale R, Bucholz Kathleen K, Madden Pamela A F, Montgomery Grant W
Abstract excerpt
BACKGROUND: Given moderately strong genetic contributions to variation in alcoholism and heaviness of drinking (50% to 60% heritability) with high correlation of genetic influences, we have conducted a quantitative trait genome-wide association study (GWAS) for phenotypes related to alcohol use and dependence. METHODS: Diagnostic interview and blood/buccal samples were obtained from sibships ascertained through...
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