Article
Genome-wide polygenic scores for age at onset of alcohol dependence and association with alcohol-related measures.
Translational psychiatry - 22 Mar 2016
Kapoor M, Chou Y-L, Edenberg H J, Foroud T, Martin N G, Madden P A F, Wang J C, Bertelsen S, Wetherill L, Brooks A, Chan G, Hesselbrock V, Kuperman S, Medland S E, Montgomery G, Tischfield J, Whitfield J B, Bierut L J, Heath A C, Bucholz K K, Goate A M, Agrawal A
Abstract excerpt
Age at onset of alcohol dependence (AO-AD) is a defining feature of multiple drinking typologies. AO-AD is heritable and likely shares genetic liability with other aspects of alcohol consumption. We examine whether polygenic variation in AO-AD, based on a genome-wide association study (GWAS), was associated with AO-AD and other aspects of alcohol consumption in two independent samples. Genetic risk scores (GRS)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.