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Primary immunodeficiency syndromes associated with defective DNA double-strand break repair

11 Sept 2006

Abstract excerpt

Damaging DNA double-strand breaks (DNA-DSBs) following ionizing radiation (IR) exposure, potentially lead to cell death or carcinogenesis. Non-homologous end-joining (NHEJ) is the main repair pathway employed by vertebrate cells to repair such damage. Many repair pathway proteins have been identified. The creation of many diverse lymphocyte receptors to identify potential pathogens has evolved by breaking and...

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PMID: 16971555
DOI: 10.1093/bmb/ldl006

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