Article
Hypoxic Induction of Exosome Uptake through Proteoglycan-Dependent Endocytosis Fuels the Lipid Droplet Phenotype in Glioma.
Molecular cancer research : MCR - 1 Mar 2021
Cerezo-Magaña Myriam, Christianson Helena C, van Kuppevelt Toin H, Forsberg-Nilsson Karin, Belting Mattias
Abstract excerpt
As an adaptive response to hypoxic stress, aggressive tumors rewire their metabolic phenotype into increased malignant behavior through extracellular lipid scavenging and storage in lipid droplets (LD). However, the underlying mechanisms and potential lipid source retrieved in the hypoxic tumor microenvironment remain poorly understood. Here, we show that exosome-like extracellular vesicles (EV), known as...
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