Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chemical genetics-based target identification in drug discovery.

Annual review of pharmacology and toxicology - 1 Jan 2012

Cong Feng, Cheung Atwood K, Huang Shih-Min A

Abstract excerpt

Identification of novel, validated targets remains a top priority in modern drug discovery. Chemical genetics represents a powerful approach to the discovery of new targets. Unlike the traditional target-based screen that relies on a predefined, sometimes poorly validated target, a chemical genetics-based phenotypic screen probes the entire molecular signaling pathway in an efficient and unbiased manner for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Drug Delivery Systems
Share to Drug Design

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Discovery

Share to Gene Expression Profiling

Share to Pharmacogenetics

Share to Proteomics

Share to Transcription, Genetic

Source

Identifiers

PMID: 21819237
DOI: 10.1146/annurev-pharmtox-010611-134639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chemical genetics-based target identification in drug discovery.PMID 21819237Read ↗

Chemical genetics: elucidating biological systems with small-molecule compounds.Semantic proximity Read ↗

Chemical genetics: an evolving toolbox for target identification and lead optimization.Semantic proximity Read ↗

Advances in chemical genetics.Semantic proximity Read ↗

An in silico Approach for Integrating Phenotypic and Target-based Approaches in Drug Discovery.Semantic proximity Read ↗

The emerging field of chemical genetics: potential applications for pesticide discovery.Semantic proximity Read ↗

Plant Chemical Genetics: From Phenotype-Based Screens to Synthetic Biology.Semantic proximity Read ↗

From Phenotypic Hit to Chemical Probe: Chemical Biology Approaches to Elucidate Small Molecule Action in Complex Biological Systems.Semantic proximity Read ↗

Forward chemical genetic screening.Semantic proximity Read ↗

Chemical genetic approaches for the elucidation of signaling pathways.Semantic proximity Read ↗

Frontiers in chemical genetics.Semantic proximity Read ↗

Target identification and mechanism of action in chemical biology and drug discovery.Semantic proximity Read ↗

Chemical genetics: where genetics and pharmacology meet.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.