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Article

Identification and validation of bioactive small molecule target through phenotypic screening.

Bioorganic & medicinal chemistry - 15 Mar 2012

Cho Yoon Sun, Kwon Ho Jeong

Abstract excerpt

For effective bioactive small molecule discovery and development into new therapeutic drug, a systematic screening and target protein identification is required. Different from the conventional screening system, herein phenotypic screening in combination with multi-omics-based target identification and validation (MOTIV) is introduced. First, phenotypic screening provides visual effect of bioactive small...

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PMID: 22153994
DOI: 10.1016/j.bmc.2011.11.021

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