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Article

Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival.

The Journal of cell biology - 4 Jan 2021

Fukuda Yusuke, Pazyra-Murphy Maria F, Silagi Elizabeth S, Tasdemir-Yilmaz Ozge E, Li Yihang, Rose Lillian, Yeoh Zoe C, Vangos Nicholas E, Geffken Ezekiel A, Seo Hyuk-Soo, Adelmant Guillaume, Bird Gregory H, Walensky Loren D, Marto Jarrod A, Dhe-Paganon Sirano, Segal Rosalind A

Abstract excerpt

Complex neural circuitry requires stable connections formed by lengthy axons. To maintain these functional circuits, fast transport delivers RNAs to distal axons where they undergo local translation. However, the mechanism that enables long-distance transport of RNA granules is not yet understood. Here, we demonstrate that a complex containing RNA and the RNA-binding protein (RBP) SFPQ interacts selectively with...

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Identifiers

PMID: 33284322
DOI: 10.1083/jcb.202005051
PMCID: PMC7721913

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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