Article

Fast Transport of RNA Granules by Direct Interactions with KIF5A/KLC1 Motors Prevents Axon Degeneration

2020-02-03

Abstract excerpt

Complex neural circuitry requires stable connections formed by lengthy axons. To maintain these functional circuits, fast transport delivers RNAs to distal axons where they undergo local translation. However, the mechanism that enables long distance transport of non-membrane enclosed organelles such as RNA granules is not known. Here we demonstrate that a complex containing RNA and the RNA-binding protein (RBP) SF...

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Literature Corpus work: 489b46f2-de59-5585-9fdc-39637aadce1e
DOI: 10.1101/2020.02.02.931204

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