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Article

An ALS-associated KIF5A mutant forms oligomers and aggregates and induces neuronal toxicity.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2022

Nakano Juri, Chiba Kyoko, Niwa Shinsuke

Abstract excerpt

KIF5A is a kinesin superfamily motor protein that transports various cargos in neurons. Mutations in Kif5a cause familial amyotrophic lateral sclerosis (ALS). These ALS mutations are in the intron of Kif5a and induce mis-splicing of KIF5A mRNA, leading to splicing out of exon 27, which in human KIF5A encodes the cargo-binding tail domain of KIF5A. Therefore, it has been suggested that ALS is caused by loss of...

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Identifiers

PMID: 35430760
DOI: 10.1111/gtc.12936
PMCID: PMC9322661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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