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Axonal transport deficit in a KIF5A –/– mouse model

31 Mar 2012

Abstract excerpt

Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder preferentially affecting the longest corticospinal axons. More than 40 HSP genetic loci have been identified, among them SPG10, an autosomal dominant HSP caused by point mutations in the neuronal kinesin heavy chain protein KIF5A. Constitutive KIF5A knockout (KIF5A( -/- )) mice die early after birth. In these mice, lungs were unexpanded, and cell...

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PMID: 22466687
DOI: 10.1007/s10048-012-0324-y

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