Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TrpML-mediated astrocyte microdomain Ca2+ transients regulate astrocyte-tracheal interactions.

eLife - 7 Dec 2020

Ma Zhiguo, Freeman Marc R

Abstract excerpt

Astrocytes exhibit spatially-restricted near-membrane microdomain Ca2+transients in their fine processes. How these transients are generated and regulate brain function in vivo remains unclear. Here we show that Drosophila astrocytes exhibit spontaneous, activity-independent microdomain Ca2+ transients in their fine processes. Astrocyte microdomain Ca2+ transients are mediated by the TRP channel TrpML, stimulated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholine
Share to Astrocytes
Share to Calcium Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gamma-Aminobutyric Acid

Share to Membrane Microdomains

Share to Tetrodotoxin

Share to Trachea

Share to Transient Receptor Potential Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 33284108
DOI: 10.7554/eLife.58952
PMCID: PMC7721441

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TrpML-mediated astrocyte microdomain Ca2+ transients regulate astrocyte-tracheal interactions.PMID 33284108Read ↗

Tweek-dependent formation of ER-PM contact sites enables astrocyte phagocytic function and remodeling of neuronsSemantic proximity Read ↗

Distinct Ca2+ signatures of leptomeningeal fibroblast subgroups in awake mouse brains in health and inflammationSemantic proximity Read ↗

Distinct Ca <sup>2+</sup> signatures of leptomeningeal fibroblast subgroups in awake mouse brains in health and inflammationSemantic proximity Read ↗

Ca <sup>2+</sup> signaling in astrocytes is sleep-wake state specific and modulates sleepSemantic proximity Read ↗

Glial phagocytosis in developing and mature Drosophila CNS: tight regulation for a healthy brainSemantic proximity Read ↗

Mutation of a NCKX eliminates glial microdomain calcium oscillations and enhances seizure susceptibility.Semantic proximity Read ↗

<i>In situ</i> characterization of calcium fluxes in astrocytic mitochondria from the mouse striatum and hippocampusSemantic proximity Read ↗

In situ characterization of calcium fluxes in astrocytic mitochondria from the mouse striatum and hippocampusSemantic proximity Read ↗

Astrocytes regulate locomotion by orchestrating neuronal rhythmicity in the spinal network via potassium clearanceSemantic proximity Read ↗

Microglial Calcium Signaling is Attuned to Neuronal ActivitySemantic proximity Read ↗

Overexposure to apoptosis via disrupted glial specification perturbs Drosophila macrophage function and reveals roles of the CNS during injury.Semantic proximity Read ↗

Glia-derived exosomal miR-274 targets Sprouty in trachea and synaptic boutons to modulate growth and responses to hypoxia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.