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Article

Glia-derived exosomal miR-274 targets Sprouty in trachea and synaptic boutons to modulate growth and responses to hypoxia.

Proceedings of the National Academy of Sciences of the United States of America - 3 Dec 2019

Tsai Yi-Wei, Sung Hsin-Ho, Li Jian-Chiuan, Yeh Chun-Yen, Chen Pei-Yi, Cheng Ying-Ju, Chen Chun-Hong, Tsai Yu-Chen, Chien Cheng-Ting

Abstract excerpt

Secreted exosomal microRNAs (miRNAs) mediate interorgan/tissue communications by modulating target gene expression, thereby regulating developmental and physiological functions. However, the source, route, and function in target cells have not been formally established for specific miRNAs. Here, we show that glial miR-274 non-cell-autonomously modulates the growth of synaptic boutons and tracheal branches....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31666321
DOI: 10.1073/pnas.1902537116
PMCID: PMC6900535

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