Article
MicroRNA networks associated with active systemic juvenile idiopathic arthritis regulate CD163 expression and anti-inflammatory functions in macrophages through two distinct mechanisms.
Journal of leukocyte biology - 1 Jan 2018
Do Thuy, Tan Rachel, Bennett Mark, Medvedovic Mario, Grom Alexei A, Shen Nan, Thornton Sherry, Schulert Grant S
Abstract excerpt
Systemic juvenile idiopathic arthritis (SJIA) is a severe childhood arthropathy with features of autoinflammation. Monocytes and macrophages in SJIA have a complex phenotype with both pro- and anti-inflammatory properties that combine features of several well characterized in vitro conditions used to activate macrophages. An important anti-inflammatory phenotype is expression of CD163, a scavenger receptor that...
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