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Article

SkewIT: The Skew Index Test for large-scale GC Skew analysis of bacterial genomes.

PLoS computational biology - 1 Dec 2020

Lu Jennifer, Salzberg Steven L

Abstract excerpt

GC skew is a phenomenon observed in many bacterial genomes, wherein the two replication strands of the same chromosome contain different proportions of guanine and cytosine nucleotides. Here we demonstrate that this phenomenon, which was first discovered in the mid-1990s, can be used today as an analysis tool for the 15,000+ complete bacterial genomes in NCBI's Refseq library. In order to analyze all 15,000+...

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Identifiers

PMID: 33275607
DOI: 10.1371/journal.pcbi.1008439
PMCID: PMC7717575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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