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Article

A novel skew analysis reveals substitution asymmetries linked to genetic code GC-biases and PolIII a-subunit isoforms.

DNA research : an international journal for rapid publication of reports on genes and genomes - 1 Aug 2016

Apostolou-Karampelis Konstantinos, Nikolaou Christoforos, Almirantis Yannis

Abstract excerpt

Strand biases reflect deviations from a null expectation of DNA evolution that assumes strand-symmetric substitution rates. Here, we present strong evidence that nearest-neighbour preferences are a strand-biased feature of bacterial genomes, indicating neighbour-dependent substitution asymmetries. To detect such asymmetries we introduce an alignment free index (relative abundance skews). The profiles of relative...

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Identifiers

PMID: 27345720
DOI: 10.1093/dnares/dsw021
PMCID: PMC4991834

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