Article
Atypical at skew in Firmicute genomes results from selection and not from mutation.
PLoS genetics - 1 Sept 2011
Charneski Catherine A, Honti Frank, Bryant Josephine M, Hurst Laurence D, Feil Edward J
Abstract excerpt
The second parity rule states that, if there is no bias in mutation or selection, then within each strand of DNA complementary bases are present at approximately equal frequencies. In bacteria, however, there is commonly an excess of G (over C) and, to a lesser extent, T (over A) in the replicatory leading strand. The low G+C Firmicutes, such as Staphylococcus aureus, are unusual in displaying an excess of A over...
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