Article
The melanoma brain metastatic microenvironment: aldolase C partakes in shaping the malignant phenotype of melanoma cells - a case of inter-tumor heterogeneity.
Molecular oncology - 1 May 2021
Izraely Sivan, Ben-Menachem Shlomit, Sagi-Assif Orit, Meshel Tsipi, Malka Sapir, Telerman Alona, Bustos Matias A, Ramos Romela Irene, Pasmanik-Chor Metsada, Hoon Dave S B, Witz Isaac P
Abstract excerpt
Previous studies indicated that microglia cells upregulate the expression of aldolase C (ALDOC) in melanoma cells. The present study using brain-metastasizing variants from three human melanomas explores the functional role of ALDOC in the formation and maintenance of melanoma brain metastasis (MBM). ALDOC overexpression impacted differentially the malignant phenotype of these three variants. In the first...
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