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Article

Common germline-somatic variant interactions in advanced urothelial cancer

3 Dec 2020

Abstract excerpt

The prevalence and biological consequences of deleterious germline variants in urothelial cancer (UC) are not fully characterized. We performed whole-exome sequencing (WES) of germline DNA and 157 primary and metastatic tumors from 80 UC patients. We developed a computational framework for identifying putative deleterious germline variants (pDGVs) from WES data. Here, we show that UC patients harbor a high...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 33273457
DOI: 10.1038/s41467-020-19971-8

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