Cancer Susceptibility Mutations in Patients With Urothelial Malignancies.

doi:10.1200/JCO.19.01395

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Article

Cancer Susceptibility Mutations in Patients With Urothelial Malignancies.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Feb 2020

Carlo Maria I, Ravichandran Vignesh, Srinavasan Preethi, Bandlamudi Chaitanya, Kemel Yelena, Ceyhan-Birsoy Ozge, Mukherjee Semanti, Mandelker Diana, Chaim Joshua, Knezevic Andrea, Rana Satshil, Fnu Zarina, Breen Kelsey, Arnold Angela G, Khurram Aliya, Tkachuk Kaitlyn, Cipolla Catharine K, Regazzi Ashley, Hakimi A Ari, Al-Ahmadie Hikmat, Dalbagni Guido, Cadoo Karen A, Walsh Michael F, Teo Min-Yuen, Funt Samuel A, Coleman Jonathan A, Bochner Bernard H, Iyer Gopa, Solit David B, Stadler Zsofia K, Zhang Liying, Rosenberg Jonathan E, Taylor Barry S, Robson Mark E, Berger Michael F, Vijai Joseph, Bajorin Dean F, Offit Kenneth

Abstract excerpt

PURPOSE: Urothelial cancers (UCs) have a substantial hereditary component, but, other than their association with Lynch syndrome, the contribution of genetic risk factors to UC pathogenesis has not been systematically defined. We sought to determine the prevalence of pathogenic/likely pathogenic (P/LP) germline variants in patients with UC and identify associated clinical factors. PATIENTS AND METHODS: Overall,...

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Identifiers

PMID: 31794323
DOI: 10.1200/JCO.19.01395
PMCID: PMC7351337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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