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Article

Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries

1 Dec 2020

Abstract excerpt

Glioblastoma is a severe type of brain tumor with a poor prognosis and few therapy options. Temozolomide (TMZ) is one of these options, however, with limited success, and failure is mainly due to tumor resistance. In this work, genome-wide CRISPR-Cas9 lentiviral screen libraries for gene knockout or activation were transduced in the human glioblastoma cell line, aiming to identify genes that modulate TMZ...

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PMID: 33271924
DOI: 10.3390/cells9122573

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