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Radiation-induced DNA damage and repair effects on 3D genome organization

2 Dec 2020

Abstract excerpt

The three-dimensional structure of chromosomes plays an important role in gene expression regulation and also influences the repair of radiation-induced DNA damage. Genomic aberrations that disrupt chromosome spatial domains can lead to diseases including cancer, but how the 3D genome structure responds to DNA damage is poorly understood. Here, we investigate the impact of DNA damage response and repair on 3D...

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PMID: 33268790
DOI: 10.1038/s41467-020-20047-w

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