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Article

2'3'-cGAMP triggers a STING- and NF-κB-dependent broad antiviral response in Drosophila.

Science signaling - 1 Dec 2020

Cai Hua, Holleufer Andreas, Simonsen Bine, Schneider Juliette, Lemoine Aurélie, Gad Hans Henrik, Huang Jingxian, Huang Jieqing, Chen Di, Peng Tao, Marques João T, Hartmann Rune, Martins Nelson E, Imler Jean-Luc

Abstract excerpt

We previously reported that an ortholog of STING regulates infection by picorna-like viruses in Drosophila In mammals, STING is activated by the cyclic dinucleotide 2'3'-cGAMP produced by cGAS, which acts as a receptor for cytosolic DNA. Here, we showed that injection of flies with 2'3'-cGAMP induced the expression of dSTING-regulated genes. Coinjection of 2'3'-cGAMP with a panel of RNA or DNA viruses resulted in...

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Identifiers

PMID: 33262294
DOI: 10.1126/scisignal.abc4537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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