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Stimulator of interferon genes (STING) provides insect antiviral immunity by promoting Dredd caspase–mediated NF-κB activation

6 Jun 2018

Abstract excerpt

The antiviral cGMP–AMP (cGAMP)–stimulator of interferon genes (STING) pathway is well characterized in mammalian cells. However, whether this pathway also plays a role in insect antiviral immunity is unknown. In this study, we found that cGAMP is produced in silkworm ( Bombyx mori ) cells infected with nucleopolyhedrovirus (NPV). In searches for STING-related sequences, we identified BmSTING , a potential cGAMP...

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PMID: 29875158
DOI: 10.1074/jbc.ra117.000194

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