Article
Actin flow-dependent and -independent force transmission through integrins.
Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 2020
Driscoll Tristan P, Ahn Sang Joon, Huang Billy, Kumar Abhishek, Schwartz Martin A
Abstract excerpt
Integrin-dependent adhesions mediate reciprocal exchange of force and information between the cell and the extracellular matrix. These effects are attributed to the "focal adhesion clutch," in which moving actin filaments transmit force to integrins via dynamic protein interactions. To elucidate these processes, we measured force on talin together with actin flow speed. While force on talin in small lamellipodial...
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