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Article

Role of Glutathione in Buffering Excess Intracellular Copper in Streptococcus pyogenes.

mBio - 1 Dec 2020

Stewart Louisa J, Ong Cheryl-Lynn Y, Zhang May M, Brouwer Stephan, McIntyre Liam, Davies Mark R, Walker Mark J, McEwan Alastair G, Waldron Kevin J, Djoko Karrera Y

Abstract excerpt

Copper (Cu) is an essential metal for bacterial physiology but in excess it is bacteriotoxic. To limit Cu levels in the cytoplasm, most bacteria possess a transcriptionally responsive system for Cu export. In the Gram-positive human pathogen Streptococcus pyogenes (group A Streptococcus [GAS]), this system is encoded by the copYAZ operon. This study demonstrates that although the site of GAS infection represents...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33262259
DOI: 10.1128/mBio.02804-20
PMCID: PMC7733945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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