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Streptococcus pyogenes Hijacks Host Glutathione for Growth and Innate Immune Evasion

25 Apr 2022

Abstract excerpt

During infection, microbes must escape host immune responses and survive exposure to reactive oxygen species produced by immune cells. Here, we identify the ABC transporter substrate binding protein GshT as a key component of the glutathione salvage pathway in glutathione-auxotrophic GAS. Host-acquired glutathione is crucial to the GAS antioxidant defense system, facilitating escape from the host innate immune...

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Identifiers

PMID: 35467425
DOI: 10.1128/mbio.00676-22

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