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Article

Loss of the glucocorticoid receptor causes accelerated ovarian ageing in zebrafish.

Proceedings. Biological sciences - 9 Dec 2020

Faught Erin, Santos Helio B, Vijayan Mathilakath M

Abstract excerpt

Reproductive decline in mid-adult females is an established phenotype of the ageing process. Stress and the rise in glucocorticoids (GCs) accelerate reproductive ageing, but little is known about the mechanisms involved. During stress, GCs activate the glucocorticoid receptor (GR), a ubiquitously expressed, ligand-bound transcription factor, to elicit physiological changes for restoring homeostasis. Here, we...

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Identifiers

PMID: 33259761
DOI: 10.1098/rspb.2020.2190
PMCID: PMC7739937

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