Article

Deciphering the Dichotomy: The Role of Glucocorticoid Receptor Isoforms in Cortisol’s Paradoxical Impact on Reproduction and Pregnancy

2023-07-04

Abstract excerpt

Alterations in the hypothalamic-pituitary-adrenal (HPA) axis and associated changes in circulating levels of glucocorticoids are integral to an organism's response to stressful stimuli. Glucocorticoids acting via glucocorticoid receptors (GR) play a role in fertility, reproduction, placental function, and fetal development. GRs are ubiquitously expressed throughout the female reproductive system and regulate norma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 52406b0a-134f-5459-a48d-ad28d78c7d75
DOI: 10.20944/preprints202306.2241.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deciphering the Dichotomy: The Role of Glucocorticoid Receptor Isoforms in Cortisol’s Paradoxical Impact on Reproduction and PregnancyDOI 10.20944/preprints202306.2241.v1Read

Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveriesSemantic proximity Read

The role of the glucocorticoid receptor signalling pathway within the human endometriumSemantic proximity Read

The origin and functions of multiple human glucocorticoid receptor isoforms.Semantic proximity Read

The glucocorticoid receptor: coding a diversity of proteins and responses through a single gene.Semantic proximity Read

The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid SensitivitySemantic proximity Read

Cellular Processing of the Glucocorticoid Receptor Gene and Protein: New Mechanisms for Generating Tissue-specific Actions of GlucocorticoidsSemantic proximity Read

Expression Profiles of Glucocorticoid Receptor α- and β-Isoforms in Diverse Physiological and Pathological ConditionsSemantic proximity Read

The Human Glucocorticoid Receptor Beta: From Molecular Mechanisms to Clinical ImplicationsSemantic proximity Read

Comprehensive overview of the structure and regulation of the glucocorticoid receptor.Semantic proximity Read

The human placenta expresses multiple glucocorticoid receptor isoforms that are altered by fetal sex, growth restriction and maternal asthmaSemantic proximity Read

Dexamethasone and sex regulate placental glucocorticoid receptor isoforms in miceSemantic proximity Read

Human glucocorticoid receptor isoform β: recent understanding of its potential implications in physiology and pathophysiologySemantic proximity Read