Article
Ulcerative Colitis-associated E. coli pathobionts potentiate colitis in susceptible hosts.
Gut microbes - 9 Nov 2020
Yang Hyungjun, Mirsepasi-Lauridsen Hengameh Chloé, Struve Carsten, Allaire Joannie M, Sivignon Adeline, Vogl Wayne, Bosman Else S, Ma Caixia, Fotovati Abbas, Reid Gregor S, Li Xiaoxia, Petersen Andreas Munk, Gouin Sébastien G, Barnich Nicolas, Jacobson Kevan, Yu Hong Bing, Krogfelt Karen Angeliki, Vallance Bruce A
Abstract excerpt
Ulcerative colitis (UC) is a chronic inflammatory condition linked to intestinal microbial dysbiosis, including the expansion of E. coli strains related to extra-intestinal pathogenic E. coli. These "pathobionts" exhibit pathogenic properties, but their potential to promote UC is unclear due to the lack of relevant animal models. Here, we established a mouse model using a representative UC pathobiont strain...
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