Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational activation of the AmgRS two-component system in aminoglycoside-resistant Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 May 2013

Lau Calvin Ho-Fung, Fraud Sebastien, Jones Marcus, Peterson Scott N, Poole Keith

Abstract excerpt

The amgRS operon encodes a presumed membrane stress-responsive two-component system linked to intrinsic aminoglycoside resistance in Pseudomonas aeruginosa. Genome sequencing of a lab isolate showing modest pan-aminoglycoside resistance, strain K2979, revealed a number of mutations, including a substitution in amgS that produced an R182C change in the AmgS sensor kinase product of this gene. Introduction of this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminoglycosides
Share to Anti-Bacterial Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Gene Expression Regulation, Bacterial

Share to Genome, Bacterial

Share to Operon

Share to Pseudomonas aeruginosa

Share to Pseudomonas Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 23459488
DOI: 10.1128/AAC.00170-13
PMCID: PMC3632935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational activation of the AmgRS two-component system in aminoglycoside-resistant Pseudomonas aeruginosa.PMID 23459488Read ↗

AmgRS-mediated envelope stress-inducible expression of the mexXY multidrug efflux operon of Pseudomonas aeruginosa.Semantic proximity Read ↗

Targeting a bacterial stress response to enhance antibiotic action.Semantic proximity Read ↗

Potentiation of Aminoglycoside Activity in Pseudomonas aeruginosa by Targeting the AmgRS Envelope Stress-Responsive Two-Component SystemSemantic proximity Read ↗

Transcriptional and Mutational Profiling of an Aminoglycoside-Resistant Pseudomonas aeruginosa Small-Colony Variant.Semantic proximity Read ↗

Mutations in Gene fusA1 as a Novel Mechanism of Aminoglycoside Resistance in Clinical Strains of Pseudomonas aeruginosa.Semantic proximity Read ↗

Molecular and Computational Insights of Novel Mutations in Aminoglycoside-Modifying Genes of P. aeruginosa.Semantic proximity Read ↗

Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides.Semantic proximity Read ↗

Multiple mutations lead to MexXY-OprM-dependent aminoglycoside resistance in clinical strains of Pseudomonas aeruginosa.Semantic proximity Read ↗

Genome-scale identification method applied to find cryptic aminoglycoside resistance genes in Pseudomonas aeruginosa.Semantic proximity Read ↗

Reverse engineering antibiotic sensitivity in a multidrug-resistant Pseudomonas aeruginosa isolate.Semantic proximity Read ↗

Mutational Activation of Antibiotic-Resistant Mechanisms in the Absence of Major Drug Efflux Systems of Escherichia coli.Semantic proximity Read ↗

Exploring molecular mechanisms of aminoglycoside resistance in Escherichia coli MG1655 using the antibiotic resistance growth plate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.