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Unexpected diversity of CRISPR unveils some evolutionary patterns of repeated sequences in Mycobacterium tuberculosis

30 Nov 2020

Abstract excerpt

BACKGROUND: Diversity of the CRISPR locus of Mycobacterium tuberculosis complex has been studied since 1997 for molecular epidemiology purposes. By targeting solely the 43 spacers present in the two first sequenced genomes (H37Rv and BCG), it gave a biased idea of CRISPR diversity and ignored diversity in the neighbouring cas-genes. RESULTS: We set up tailored pipelines to explore the diversity of CRISPR-cas...

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PMID: 33256602
DOI: 10.1186/s12864-020-07178-6

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