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Article

Genetic variation and evolutionary origin of the direct repeat locus of Mycobacterium tuberculosis complex bacteria.

Journal of bacteriology - 1 May 2000

van Embden J D, van Gorkom T, Kremer K, Jansen R, van Der Zeijst B A, Schouls L M

Abstract excerpt

The direct repeat region in Mycobacterium tuberculosis complex strains is composed of multiple direct variant repeats (DVRs), each of which is composed of a 36-bp direct repeat (DR) plus a nonrepetitive spacer sequence of similar size. It has been shown previously that clinical isolates show extensive polymorphism in the DR region by the variable presence of DVRs, and this polymorphism has been used in the...

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Identifiers

PMID: 10762237
DOI: 10.1128/JB.182.9.2393-2401.2000
PMCID: PMC111299

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