Article
Vulvar Pilomatrix Carcinoma: Morphologic and Molecular Features.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Sept 2021
Bueno Diego, Caniego-Casas Tamara, Sánchez-Martínez María Concepción, Saavedra-Serrano Cristina, Palacios José, Pérez-Mies Belén
Abstract excerpt
Pilomatrix carcinoma (PC) is a rare malignant variant of pilomatrixoma, a skin adnexal tumor originating from hair matrix cells. It is most often located in the head, neck region, upper back and upper extremities. PC has a locally aggressive behavior but metastasis only occur in 10% of cases. Mutations in CTNNB1, the encoding gene of beta-catenin, have been found in both pilomatrixoma and PC, but other molecular...
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